GPR75 - Probable G-protein coupled receptor 75

Probable G-protein coupled receptor 75 is a protein that in humans is encoded by the GPR75 gene. GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand. GPR75 is currently classified as an orphan GPCR and several studies are underway to identify its ligand. In one study, the chemokine CCL5 (RANTES) has been shown to stimulate calcium mobilization and inositol triphosphate formation in GPR75-transfected cells. GPR75 is rare mutation gene, leading to only one working copy of it. Being in this rare group of people is associated with a lower body weight and 54 percent lower odds of obesity. These results are consistent across multiple ancestries, environmental exposures and genetic backgrounds, and they strongly suggest GPR75 is one of many genes involved in weight gain.

Gene location in human

Whole exome sequencing, which can help us find mutations in certain genes and therefore reveal their effects. Instead of sequencing each and every gene in the human genome, exome sequencing focuses only on exons, which make up about one percent of all DNA. Exons are the pieces that provide instructions for proteins, which means when you sequence this entire subset you can identify mutations in protein-coding regions of any gene. Such variations are generally quite rare, but when they are found, they "self-identify" causative genes.

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NVIDIA Tesla V100 - First Tensor Core GPU

8x NVIDIA Tesla V100 32GB Server As we all know NVIDIA processor are so famous now a days. It give a perfect gaming performance and people used it worldwide. The thing is that it is not only use in personal computer but also at data center, where so many super computer are present for providing services. So, NVIDIA Tesla V100 is a first tensor core GPU. It is especially built to focus on AI, High Performance Computing ( HPC ) and graphics. It is powered by NVIDIA Volta Architecture. It comes with configuration 16 and 32GB and have a performance up to 100 CPUs in single GPU. A single server node with V100 GPUs can replace 60 CPUs nodes. DATA CENTER GPUs Image © NVIDIA NVIDIA V100 for NVLINK Performance with NVIDIA GPU Boost for double precision is 7.8 teraflops and single precision is 15.7 teraflops. Deep learning performance boost is 125 teraflops. Interconnect bandwidth with bidirectional is 300 GB/s. It have memory capacity of 32/16 GB HBM2 with bandwidth 900GB/s. I...

The Amazing Vantablack Material...!!

Vantablack is a material developed by Surrey NanoSystems in the United Kingdom and is one of the darkest substances known, absorbing up to 99.96% of visible light (at 663 nm if the light is perpendicular to the material).The name is a compound of the acronym VANTA (vertically aligned carbon nanotube arrays) and the color black. Vantablack is not actually a color pigment or a paint, but a coating of carbon nanotubes. These have the property of absorbing incident light almost completely. Against a deep black background, objects coated in Vantablack material seem to disappear, as the perception of spatial depth is lost. This is because the human eye perceives shapes coated in Vantablack to be two-dimensional. IUPAC Name is Activated carbon high density skeleton. Other names are Multiwalled carbon nanotube (MWCNT), Vantablack S-VIS and Vantablack S-IR. It is insoluble in water. When light strikes Vantablack, instead of bouncing off, it becomes trapped and is continually deflected amo...

Operating System as Extended machine and Resource manager

Operating system is software that runs in kernel mode even that is not always true. Part of the problem is that operating system perform two essential unrelated function. We can say that operating system is system software that manages computer hardware, software resources, and provide common services for computer program. The Operating System as an Extended machine The architecture of most computers at the machine language level is not developed and difficult to program, especially for input/output. To make this point more concrete, consider modern SATA hard disks used on most computers. Only the insane the programmer would try to mess with hard disks at the hardware level. Therefore disk driver - a piece of software deals with hardware and provide interface to read and write disks blocks. Operating System contain many drivers for control input/output device. Macintosh hardware are complicated. Real processors, memories, disks, and other devices are very complicated and it...

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